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inTrigue - Impact on your rare disease business

Volv has spent three years developing its flagship product called inTrigue, which finds misdiagnosed and undiagnosed rare disease patients from electronic health care records (EHRs). inTrigue is based on an entirely original use of artificial intelligence and machine learning, together with a set of established in-country processes that access tens of millions of EHRs.

What inTrigue does is fundamentally change the nature of your understanding of prevalence in each country you are interested in. By deriving highly accurate models for identifying patient cohorts, we deliver empirically based prevalence numbers which are then optionally validated by expert clinicians in the medical setting.

This can have a profound impact on your business, as armed with some concrete numbers, your organisation can consolidate their activities around one set of numbers rather than several contested scientific papers. Not only that, when engaging with regulatory authorities and payers, the substantive evidence based position can stand you in good stead getting the respect and trust that helps obtaining the approvals that you need.

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An extra lens: for the whole of your market strategy


The inTrigue approach is designed to bring 4 Primary Streams for improved Quality Outcomes which impact on your whole organisation:

  • Epidemiology
    • it is revised to an evidenced baseline, with sophisticated stratification capabilities
  • HEOR/Market Access
    • the market access conversation is revised to enable value delivery to clinicians, patients and payers to your advantage by our approach
  • Clinical Decision-Making Logic
    • we discover and create new predictive biomarkers with the potential to improve decision making logic in real world clinical use which are resolved in an understandable way with interpretable models
  • Publications
    • dissemination of results through publications enhances scientific reputation and educates the clinical world

Market Access Framework & Roadmap

Market Access Framework Map

inTrigue is not just a data science activity at the core but is also part of a whole methodology that implicates many players in your organisation.

The customers that get the most value from Volv, actively engage different teams from project inception.

Fundamental to what we do is stay rigorous in terms of the scientific basis of what we are discovering:

  • Prevalence
  • Digital Biomarkers
  • Predictive disease models with measurable performance
  • Clinically interpretable models
  • Scientific publications that show the results of the disease models derived
  • The ability to deploy models in a way that improves quality of care

These deliverables all have potential across the organisation, and while our activities are not commercial, but remain closely constrained as a scientific endeavour, we find that your commercial organisation are always keen to be kept informed.

Summary

Volv has built completely new proprietary approaches for Rare Diseases that are proven in previous work as well as in other settings and our methodology is based on many years of proven experience in highly critical settings.

We airgap commercial engagement from clinical/scientific engagement in tightly regulated countries

We understand the need to optimise revenues versus costs, so focus on applying the methods and technology to those aims

You can leverage our methods into targeted activities such as clinical and direct patient engagement, which we have experience in as well.

The inTrigue methodology blends original data science with a set of robust delivery processes to find undiagnosed and misdiagnosed rare disease patients. Rare disease pharmaceutical companies that choose to adopt inTrigue – as distinct from taking either a traditional approach or a conventional AI search approach – can expect to achieve an increase in addressable market size, combined with a significant reduction in cost of patient treatment.

inTrigue Business Case

By finding more patients and finding them earlier and with greater accuracy, inTrigue helps more patients to be treated for longer. The greater accuracy also ensures that you remove risk of inappropriate treatment.

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inTrigue Case Study

By finding more patients and finding them earlier and with greater accuracy, inTrigue helps more patients to receive the appropriate treatment, to the benefit of all.

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